For FEV1, among the 12 SNPs tested for replication, eight SNPs from one locus with four adjacent genes were significantly associated with this measure in SpiroMeta, including rs17331332 and rs17036341 near NPNT, rs11727189 and rs17036090 in or near INTS12, rs17036052 and rs17035960 in or near FLJ20184, and rs11097901 and rs11728716 in GSTCD (Table 3). For replicated SNPs, the allele frequencies and the direction and magnitude of the associations with FEV1 were similar between consortia, and P values from joint meta-analysis ranged from 4.66×10−17 to 9.42×10−14 (Table 2). None of these SNPs were significantly associated with FEV1/FVC in CHARGE or SpiroMeta (Supplementary Table 5).
