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Chunk #18 — 3. Insights and Limitations from GWAS of AD — 3.1 Genetic Variation: Common and Rare Variants

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The genetics of alcohol dependence: advancing towards systems-based approaches.
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et al., 2011), thus demonstrating that cumulative/aggregate genetic risk scores should prove useful in capturing more of the missing heritability (De Jager et al., 2009; Kohli et al., 2010; Purcell et al., 2009). However, a notable limitation of these models is that they lack the degree of specificity needed to inform the development of prevention/treatment tools.