Neither of the TLL1 SNPs, rs6812849 and rs7691872, was significantly associated with PTSD in AAs. Because AA is an admixed population with ~20% European ancestry (30), we estimated the local ancestry around the two TLL1 SNPs of the GWAS AA subjects using HAPMIX (27). Local estimated European ancestry of each subject was adjusted in the logistic regression model. Nevertheless, no significant association was observed (rs6812849, p = .68; rs7691872, p = .48). Among the 2766 AAs, 2266 had local African ancestry ≥50%. We restricted our analysis to these subjects, and no significant association was observed (rs6812849, p = .95; rs7691872, p = .90).
