considering both dispersion and zero-inflation is further emphasized by the comparisons of ZIP with ZINB and NB with ZINB. In conclusion, based on Vuong’s test, for Ion Proton sequencing dataset, the most appropriate distribution is ZINB, followed by NB, ZIP and Poisson.Table 1Vuong’s non-nested tests on 4 distributions applied to Ion Proton training dataModel 1Model 2Vuong z-statistic BIC-correctedHypothesis P valuePoissonNB−122.67model2 > model1<2.22e-16PoissonZIP−143.73model2 > model1<2.22e-16NBZIP36.81model1 > model2<2.22e-16ZIPZINB−92.16model2 > model1<2.22e-16NBZINB−119.51model2 > model1<2.22e-16
