the independent method, rendering differences more reflective of true developmental effects rather than misregistration. Considering known growth patterns (Lenroot et al., 2007; Sowell et al., 2004a), we predicted that 1) cortical tissue volumes would decline, 2) ventricular and cortical sulcal volumes would expand, and 3) the sequential method of registration would detect these changes more readily than the independent method. As a test of convergent validity of the method, changes in regional brain volumes using each registration approach were correlated with changes observed in Tanner stages.
