In a large nationally representative sample, the lifetime probability of treatment-seeking was highest for drug dependence, followed by drug abuse, alcohol dependence, and alcohol abuse. A history of SUD treatment increased the probability of treatment for all SUD disorders while a history of mental health treatment only increased the probability of treatment for alcohol abuse and drug dependence. A later age of onset and not receiving a college education increased the likelihood of treatment for alcohol abuse and dependence. The effects of comorbid psychiatric disorders on treatment-seeking were more complex and varied by disorder.