During childhood, offspring from high-risk families were significantly more likely to receive a diagnosis of ADHD (P = 0.006) and ODD (P = 0.001) than were low-risk controls (Table 5). During adolescence ADHD (P = 0.002), ODD (P < 0.001), Conduct Disorder (P < 0.001), Drug Abuse (P = 0.024) and Drug Dependence (P = 0.001) were elevated in association with being a member of a multiplex family. Significant risk group differences were also seen for Major Depressive Disorder (P = 0.002) (Table 5).
