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Chunk #46 — Discussion

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Genomic regions identified by overlapping clusters of nominally-positive SNPs from genome-wide studies of alcohol and illegal substance dependence.
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This evidence for replication, defined in this fashion, also provides striking contrasts to results from attempts to identify replication (and/or generalization) in other ways. For example, results that seek to identify the extent to which the same SNPs display nominally-significant associations with the same phase in each of these replicate samples within each racial/ethnic group identify about as many SNPs with these properties as expected by chance (data not shown).