et al., 2012a,b; Vanderhaeghen, 2012; Maroof et al., 2013; Nicholas et al., 2013). Most of these methods induce differentiation that approximates the in vivo developmental program. Consequently, in addition to producing a neuronal subtype, hPSCs can potentially recapitulate the developmental stages of the neuron of interest (Hu et al., 2010; Shi et al., 2012b; Nicholas et al., 2013) and provide insights into the pathogenesis of neurodevelopmental diseases where deficits originate in developmental windows prior to the onset of clinical symptoms.
