We demarcated regions containing genome-wide significant association signals by first defining the set of SNPs with r2 > 0.5 to all independent SNPs showing genome-wide significant association using a 1 Mb window of HapMap CEU data23 centered on the index SNP. SNPs were considered to be independent if they had a r2 < 0.3 in our GWAS control data. Recombination hotspots28 flanking these sets of SNPs were set as the boundaries of regions containing genome-wide significant association signals.
