Procedures for subject stimulation and imaging were as described in Kareken, et al. (2010). In brief, two fMRI sessions were conducted on separate days at a standardized time (~2:00 pm), and employed the odors of each subjects’ preferred alcoholic drinks, in addition to two sets of control odorants. Subjects were asked to refrain from drinking alcohol for 3 days prior to study. Prior to imaging, subjects were provided a light, standardized lunch in the Indiana University General Clinical Research Center. For each session, subjects underwent intravenous infusion of either alcohol or placebo (saline) in a randomized order. To minimize expectations, subjects were told that they could receive alcohol or placebo at any session (one session did not predict the other).
