FTND and COT risk scores (supplementary Figure 1B,C) were calculated for the subjects of the phase I PGC schizophrenia GWAS samples23 using the summary statistics from the FTND (n = 17,781) and COT (n = 4,548) GWAS meta-analyses. We then evaluated whether the genetic risk scores of COT and FTND could predict the schizophrenia diagnosis using logistic regression. The results were presented in Table 2. The COT risk scores calculated at the P-values of 5 × 10−5, 5 × 10−4 and 5 × 10−3 predicted schizophrenia diagnosis, but FTND risk scores failed to do so. For the P-values thresholds at which the COT risk scores predicted schizophrenia diagnosis, the beta coefficients were also positive, again, confirming the positive phenotypic correlation between ND and schizophrenia.
