Damage to the orbitofrontal cortex also interferes with the inhibition of responding to formerly rewarding cues that are no longer reinforcing, thus favoring the emergence of perseverative behaviors even when these are no longer reinforcing (reviewed in Reference 63). Thus, the dysregulated activity of the orbitofrontal cortex could underlie both the impulsive choices for immediate rewards and compulsive drug intake even when the drug-induced DA increases may be profoundly attenuated in addicted subjects (as described above).
