As previously suggested by Benedetti et al.17, this study suggests a gene/environment interaction influencing the AAO of BD and follows several previous findings suggesting that each factor separately decreases the AAO101113141516. Our data can be placed within gene/environment models of psychiatric conditions, where environmental factors can represent major risk factors for the development of mental disorders, but that their influence is modulated by the presence of susceptibility genetic variants31. Our data highlight a number of processes relevant to the onset and course of BD.
