Profile of disorder associations for illustrative pleiotropic loci: (A) rs8084351 on 18q21.2; (B) rs7193263 on 16p13.3; (C) rs117956829 on 11q14.3; and (D) rs10265001 on 7q34.For each locus, disorder-specific effects of the index SNP are shown using ForestPMPlot. The first panel is the forest plot, displaying disorder-specific association p-value, log odds ratios (ORs), and standard errors of the SNP. The meta-analysis p-value and the corresponding summary statistic are displayed on the top and the bottom of the forest plot, respectively. The second panel is the PM-plot in which X-axis represents the m-value, the posterior probability that the effect eixsts in each disorder, and the Y-axis represents the disorder-specific association p-value as -log10(p-value). Disorders are depicted as a dot whose size represents the sample size of individual GWAS. Disorders with estimated m-values of at least 0.9 are colored in red, while those with m-values less than 0.9 are marked in green.
