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Chunk #24 — FUNCTIONAL CONSEQUENCES OF A NONCODING AUD‐ASSOCIATED SNP IN KCNJ6

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5. Collaborative Study on the Genetics of Alcoholism: Functional genomics.
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Popova and colleagues 39 generated NGN2‐induced excitatory neurons from eight participants of European ancestry from the NIAAA/COGA cell repository: 4 with AUD‐linked allelic variations in KCNJ6 and 4 without, each haplotype selected for the presence (affected) or absence (unaffected) of AUD, respectively. Analysis of these participants identified additional 19 SNPs in the 3′ UTR of KCNJ6 in strong LD with the original three. Analysis focused on differences associated with this AUD‐linked, noncoding KCNJ6 haplotype in multiple genetic backgrounds.