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Chunk #25 — Online Methods — Simulation of sequencing data based on 1000 Genomes Project dataset — Data access

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Extremely low-coverage sequencing and imputation increases power for genome-wide association studies.
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The analyses presented here make use of genetic data from Autism NIMH Controls (AUT, 322 samples), the Swedish Schizophrenia control data (SCZ, 503 samples) and the International HIV Controllers Study (IHCS, 84 samples). AUT and SCZ datasets are available from dbGaP under accession numbers phs000298.v1.p1 and phs000473.v1.p1. The IHCS data is available by direct request from Pamela Richtmyer (prichtmyer@partners.org); investigators can submit a concept sheet detailing their study design, research questions and other needs in order to request access to IHCS genetic data. The concept sheet with detailed instructions can be downloaded from: http://cfar.globalhealth.harvard.edu/fs/docs/icb.topic938249.files/Harvard%20CFAR%20Concept%20Sheet%20Template%20.docx. Requests will be reviewed on the basis of scientific merit, feasibility and potential overlap with accepted concept sheets or ongoing investigations.