the lifetime co-occurrence of psychiatric and substance use disorders. PRS for individual psychiatric diagnoses (i.e., ADHD, BIP, MDD, and SCZ, but not AUT) were also significantly associated with specific substance involvement (i.e., alcohol, cannabis, cocaine, nicotine, and opioids), and are discussed in detail below. As in Results, all nominally significant substance-specific individual psychiatric diagnosis PRS associations are discussed to provide an overview of observed associations. Only the following specific PRS and substance use associations survived permutation-based correction for multiple comparisons: (A) MDD PRS with non-problem cannabis use, (B) MDD PRS with severe cocaine dependence, (C) SCZ PRS with non-problem cannabis use and severe cannabis dependence, and (D) SCZ PRS with severe cocaine dependence.
