and 0.000153. The LDpred-score results we present in this paper for our first two polygenic scores are for the scores based on a Gaussian mixture weight of 0.3 (our “preferred score”), which consistently performed well across cohorts and phenotypes.) Our third polygenic score was constructed with the classical method, which simply weights SNPs by their GWAS effect size54,55, using the summary statistics from the meta-analysis of the discovery and replication GWAS of general risk tolerance.
