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Chunk #34 — Discussion

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Neuronal generator patterns of olfactory event-related brain potentials in schizophrenia.
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The application of the CSD-PCA approach identified factors corresponding to the N1 and P2 potentials, which have been consistently observed in OERP studies (Lorig, 2000; Pause & Krauel, 2000). Schizophrenia patients and healthy controls showed a prominent N1 sink over frontotemporal sites and a corresponding mid-frontopolar source. This topography is fully compatible with postulated generators within the medial temporal lobe and/or basal cortical regions (e.g., orbital frontal cortex; cf. Martzke et al., 1997). In addition, the observed N1 sink topography was distinctly unique, that is, it did not match generator patterns previously described for early visual (e.g., Kayser et al., 2006, 2007, 2009) or auditory components (e.g., Kayser & Tenke, 2006a, 2006b; Kayser et al., 2007, 2009; Tenke et al., 2008, 2010), which strongly suggests that the underlying neuronal activity may indeed reflect an early, modality-specific processing stage during odor perception. In contrast, the P2 source had a mid-parietal topography, with current sinks over lateral frontotemporal sites, which is compatible with the notion of a close association of olfactory P2 with a classical P3b potential (e.g., Lorig, 2000; Olofsson et