Additionally, associations of rs3778150 extended in part to measures of experimental measures of alcohol sensitivity. Specifically, carriers of the rs3778150-C allele reported significantly lower levels of BAES alcohol-related stimulation (StimMax) during an alcohol challenge session, but not with self-reported levels of alcohol-related sedation (SedMax) during the alcohol challenge or subjective intoxication, despite being strongly related to overall measures of alcohol sensitivity and sensitivity to the sedative-like effects assessed by the ASQ and SRE. Mean comparisons for rs3778150 genotype groups indicated that carriers of the rs3778150-C allele reported higher levels of alcohol-related sedation (Table 1), although this difference was not significant, even when included with other covariates in the hierarchical multiple regression analyses. It may be that power issues contributed to the lack of total replication across retrospective and alcohol challenge measures of subjective response for rs3778150.
