Although PPP3CA is thus a strong candidate to play central roles in addiction and memory-associated disorders, the details of PPP3CA associations with these disorders, the detailed structure of the PPP3CA gene and its variants have not all been elucidated. We have thus sought to follow up on initial evidence for association of PPP3CA markers with substance dependence. We assemble, for the first time, a complete profile of the PPP3CA gene structure, delineating novel splice variants and polymorphisms. We define isoform-selective differences in PPP3CA expression in mRNAs extracted from AD brains. These observations point to selective roles for PPP3CA and its variants in the pathogenesis of addiction, AD and, perhaps, other disorders that involve reward and/or memory-like features.
