expression traits to neuropathology like Braak stage within the LOAD patient group was highest in the PFC region (Figure 2D). Given these observations and the fact that PFC is more commonly affected in LOAD than CB and VC (Braak and Braak, 1991), a particular attention was paid to this region in our strategy to rank-order modules for relevance to LOAD. These massive datasets were the basis of further method development with the aim to identify and rank-order network modules and gene targets associated with LOAD pathology (Figure 1A-C). Results of these various analysis steps are discussed in the sections that follow, and a more detailed description of methods and statistical procedures is found in the Extended Experimental Procedures.
