for Axis I disorders [26], rs16969968 (highly correlated with rs1051730 in European ancestry populations, and coding for CHRNA5 p.Asp398Asn, where Asn398 is associated with reduced nAChR function [77]) was observed to be associated with functional connectivity within the same FTND-associated cingulate circuit. In population samples, rs1051730 has been associated with reduced working memory performance [78]. In a laboratory study of abstinent smokers, transdermal nicotine has been associated with improvements in working memory [79]. Finally, reduced working memory performance in abstinent smokers has been associated with relapse over seven days in individuals receiving placebo and exposed to a smoking lapse [80].
