may also be that the pathways of depression and serotonergic antidepressant effect are separate but entwine through common intermediary genes. One such candidate is NRG1, identified here in depression, and also in a recent meta-analysis of antidepressant response 50. These findings suggest that there is potentially a need to concurrently model a range of ‘omics data, including genomics, epigenomics, and transcriptomics to gain further understanding of depression pharmacology.
