Recently, we established the SpiroMeta consortium and published a large collective meta-analysis of lung function genome-wide association studies (GWAS) in 20,288 individuals of European origin, with follow-up of top SNPs in a further 54,276 individuals [7], [8]. Our study confirmed the hedgehog interacting protein (HHIP) association previously published [9], [10] and identified five new loci associated with FEV1 or FEV1/FVC ratio including tensin 1 gene (TNS1), glutathione S-transferase, C-terminal domain containing (GSTCD), 5-hydroxytryptamine receptor 4 (HTR4), advanced glycosylation end product-specific receptor (AGER), and thrombospondin, type I, domain containing 4 (THSD4). A study with similar design by the CHARGE consortium also identified HHIP, AGER, HTR4, and GSTCD, and in addition suggested a potential role of five additional genes (G protein-coupled receptor 126 (GPR126), a disintegrin and metalloproteinase domain 19 (ADAM19), family with sequence similarity 13, member A (FAM13A), patched homolog 1 (PTCH1), and phosphotyrosine interaction domain containing (PID1) [8].
