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Chunk #26 — Results — Correlations with clinical scores

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Subthalamic nucleus phase-amplitude coupling correlates with motor impairment in Parkinson's disease.
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We tested whether mean PAC and spectral power values could explain some of the variability in contralateral hemibody bradykinesia/rigidity UPDRS scores. OFF and ON medication states were combined in this analysis to increase the range of UPDRS scores. Separate regression analyses were performed for the low- and high-beta ranges. Results are visualised in Fig. 4 and all correlation coefficients and p-values are reported in Table 1. We found a significant positive correlation for PAC and spectral power in the low-beta range, indicating higher PAC and power values with more severe bradykinesia and rigidity symptoms. For the high-beta range, the correlation with spectral power no longer reached significance and the correlation with PAC did not survive a Bonferroni correction for the number of pair-wise correlations performed. Additional analyses revealed that correlation coefficients were highest and p-values lowest for frequency windows centred in the low-beta range (Fig. 5). No significant correlations were found for HFO spectral power.