loci for which the target genes are significantly enriched for 3 particular TF motifs (6q25/ESR1; 9q31/KLF4, 8q24/MYC) (Table 1). Moreover, as mandated by our analysis, the particular TF whose motif is over-represented in the target genes is physically located nearby the risk locus. Of note, six of the 15 risk loci have a TF located nearby, but the TF motif is not enriched in the target genes (Table S6, related to Figure 2).
