nodes in ErGeN1 and associated with cis eQTL in the saline data. Unlike Aplp1, The ethanol response of Scn1b was at least partially regulated by a local polymorphism, as evidenced by its suggestive cis eQTL in the S-score data. Both genes contain coding polymorphisms, Aplp1's harbored a polymorphic splice site, raising the possibility that different Aplp1 isoforms may segregate members of the BXD family.