For each SNP that showed differential expression, we examined the Genotype-Tissue Expression (GTEx) database (version V8)(GTEx_Consortium, 2017) to determine whether it is a reported expression quantitative trait locus (eQTL) of the gene it resided in, and whether that gene is expressed in the brain. We annotated binding sites of RNA-binding proteins (RBP) using the ENCODE RNA Binding Protein track (Baroni et al., 2008) of the UCSC Genome Browser database (Haeussler et al., 2019). Using the Polymirts database (Bhattacharya et al., 2014) we identified miRNAs whose binding, as calculated by TargetScan (Agarwal et al., 2015), were predicted to be altered.
