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Chunk #6 — INTRODUCTION

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Practical considerations for imputation of untyped markers in admixed populations.
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We had three main objectives in this study: 1) we investigated how well different programs for imputation work for an admixed study sample consisting of African Americans; 2) we investigated how to choose an appropriate reference panel for an admixed study sample; and 3) because each program reports different measures of imputation success, we investigated measures of imputation success and the calibration of these measures across the different programs in order to draw meaningful comparisons.