kidney FGFR1-KL (59) may limit potential stress and damage from mineral overload. The effects of the FGF19 subfamily are pleiotropic and complex on both local tissue and organism levels. Detailed dissection of the action of each endocrine FGF in inter-organ or cross-tissue communication and stress relief promises to be a novel conceptual base for pursuit of complete understanding of the biology of endocrine FGFs.
