Having two AUD-affected parents had a stronger association with risk for early than later initiation for all outcomes. AUD in both parents had a stronger association with risk for use of alcohol and cigarettes before age 16 than later (alcohol: HRs=1.59 and 1.25; cigarettes: HRs=1.81 and 1.45). For first use of cannabis, having two parents with an AUD was more strongly associated with beginning use at age 12 and younger than later (HRs=2.71 and 1.32). Regarding first consensual sex, having 2 AUD-affected parents was associated with a stable 43% increased risk until age 18, after which there was no significant association (HRs=1.43 and 0.97).
