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Chunk #24 — RESULTS — Regulation of the electron transfer system by chronic nicotine treatment

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Significant modulation of mitochondrial electron transport system by nicotine in various rat brain regions.
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encoded subunits of complex IV (i.e., Mt-co1, Mt-co2, and Mt-co3) was differentially elevated in the amygdala, hippocampus, PFC, and VTA, whereas their expression was somewhat suppressed in the NA and striatum. We also identified two upregulated subunits of ATP synthase, Atp5b and Atp5j, in the amygdala, hippocampus, PFC, and VTA. Atp5j was downregulated or slightly suppressed in the NA or striatum. Consistent with the pattern of individual genes, the electron transport pathway was overrepresented in the amygdala, hippocampus, PFC, and VTA and was underrepresented in the NA and striatum.