Chunk #30 — Results — Integrating Genetic and Network Data across Species to Inform GWA Discoveries — Identifying candidate susceptibility genes for coronary artery disease and LDL cholesterol levels.
most logical candidate susceptibility gene in the 1p13.3 locus (Figure 2), although direct experimental manipulation of these two genes would be required to provide more direct functional support that these genes are involved in modulating LDL cholesterol levels. The association of this locus with LDL cholesterol levels as well as liver expression levels of SORT1, CELSR2, and PSRC1 were recently reported in multiple independent studies [17,18].
