Among the actions of alcohol on several ligand-gated ionophores such as NMDA, 5-HT3, or cholinergic receptors, the positive modulation of the GABAA receptor appears to be of particular significance with regard to aggressive behavior (Miczek et al 2002, 2003). Moreover, the interactive effects of alcohol with neurosteroids and benzodiazepines appear to be mediated by action at modulatory sites on the GABAA receptor (Grobin et al 1998; Kumar et al 2004).
