Table 2 presents the findings for the top 25 SNPs. The quality control metrics – SNP missingness, agreement with HWE, and similarity of the control MAFs to the HapMap EUR panel – for the top 25 SNPs are generally acceptable. Four of the top 25 associations are in the presynaptic cytomatrix protein piccolo (PCLO). Table 3 depicts the top 25 multi-SNP clusters (i.e., for an index SNP with association p<0.001, these clusters are additional SNPs within 250 kb of the index SNP with with r2 ≥ 0.50). The full version of this table is included as a Supplemental File (“Table3_full.xls”). PCLO is present in the top 25 clusters along with two additional multi-SNP clusters in the top 200. Other notable SNP clusters occurred in GRM7 (rank 51), DGKH (rank 83, a candidate gene for bipolar disorder) (70), DAOA (rank 124), and DRD2 (rank 226).
