Cases were compared with controls on demographic factors using χ2 tests for categorical variables and t tests for continuous variables. Hardy-Weinberg equilibrium was assessed using a χ2 goodness-of-fit test for each SNP in African American and white controls separately. Unconditional logistic regression was used to examine the effect of these SNPs on lung cancer risk, controlling for age, sex, and one of the three measures of smoking behavior: ever smoking, pack-years of smoking, or cigarettes smoked per day. Analyses were conducted separately by race for whites and African Americans. Results for models including pack-years and cigarettes smoked per day were very similar; hence, the unadjusted models and models including cigarettes per day are presented. Participants of other races (26 cases and 26 controls) were excluded from the analysis. Analyses were conducted assuming a log additive model. Analyses were repeated stratified by smoking history, family history of lung cancer in a first-degree relative, and age. A dominant model was also tested for each SNP, with carriers of one or two copies of the minor allele compared with carriers of two major
