No firm conclusions can be derived from this comparative nosology analysis, but lines of evidence are emerging. Neurological diseases essentially support the idea that long-range connectivity rather than local connectivity or misconnectivity could be an important cofactor in the expression of psychotic symptoms. The most important effect is likely to lengthen and scatter the conduction time (disconncctivity) rather than merely diminishing it (deconnectivity). Lastly, both WM lesions and a sufficient amount of dopamine seem to be required for the expression of psychosis, as the cure of one or the other is sufficient to alleviate the symptoms.
