To select transcripts which were similarly changed in the groups defined by toxicology described above and also in all 34 Group I–II cases, transcripts with average p-values ≤0.10 (or ≥0.90) for all cases were selected if (i) at least 30 cases (≈90%) had GAP scores ≤0.10 (or ≥0.90), and (ii) GAP ≤0.06 (or ≥0.94) for two (or three) of the groups defined by general toxicology.