BD patients have a higher prevalence of psychiatric comorbidities with anxiety disorder (24.1%) being most prevalent followed by personality disorders (17.5%) and PTSD (9.7%) [19]. Anxiety disorders, including panic disorders, are reported to occur in BD over the course of disease in high rates ranging from 39% to 55% [28] and PTSD [29]. However, no study has investigated this comorbidity in bipolar subjects with CUD. Comorbid anxiety disorders increase the risk for hospitalization for BD depression but not for BD mania [20]. A higher proportion of BD patients with borderline personality disorders are female and are at higher risk for suicidal behaviors, emphasizing the need for acute inpatient care [19]. Comorbid anxiety disorders increase the odds for hospitalization for BD depression and not for BD mania [28].
