The major findings of this study were that repeated i.p. injections of 1 g/kg ethanol differentially altered protein expression levels in the ACB-shell of P, NP and W rats (Tables 2 – 5), with ethanol uniquely altering expression levels of 11 of 22 proteins in the P rat, 121 of 128 proteins in the NP rat, and 17 of 28 proteins in the W rat. These differential alterations in protein expression levels among the 3 rat strains suggest a significant strain × ethanol interaction.