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Chunk #30 — 4. Discussion

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Differential effects of ethanol in the nucleus accumbens shell of alcohol-preferring (P), alcohol-non-preferring (NP) and Wistar rats: a proteomics study.
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The major findings of this study were that repeated i.p. injections of 1 g/kg ethanol differentially altered protein expression levels in the ACB-shell of P, NP and W rats (Tables 2 – 5), with ethanol uniquely altering expression levels of 11 of 22 proteins in the P rat, 121 of 128 proteins in the NP rat, and 17 of 28 proteins in the W rat. These differential alterations in protein expression levels among the 3 rat strains suggest a significant strain × ethanol interaction.