The association of the SNPs at the chromosome 4 HHIP (Hedgehog-Interacting Protein) locus is also interesting, though it did not reach the stringent genome-wide significance levels in the populations studied in this manuscript. These SNPs were also associated with FEV1 in the BEOCOPD study (rs1828591 and rs13118928, p = 0.0025 and 0.0014). The same SNPs are also associated with FEV1 in the British Birth Cohort (rs1828591 and rs13118928, p = 0.039 and 0.038, respectively) but were not associated with FEV1 in the ICGN population.
