curse”: in the larger Zeller et al.15 and Fehrmann et al.20 studies, among genes annotated in all three studies, replication in NTR was 66.8% (2,799/4,189) and 77.2% (3,404/4,412) (Figure 4b). Similarly, for local gene-SNP pairs with q<0.05 from the peripheral blood eQTL meta-analysis of Westra et al.29 (n=5,311), estimated true-discovery rates in NTR and NESDA were 59.6% and 59.7%, respectively (Supplementary Note and Supplementary Figure 8).