p-value thresholds, and thus their genetic informativeness is likely to be somewhere between a polygenic risk score based on genome-wide significant SNPs and SNP heritability as derived through methods that estimate the variance explained by genome-wide markers (e.g., GCTA; [44]). The limited amount of variance accounted for in our analyses may be attributable to the fact that GWAS-derived polygenic scores only account for common (versus rare; [45]) genetic variation; accordingly, incorporating rare genetic variation in polygenic scores may be an important direction for future research. In addition, the limited variance accounted for may also be attributable to the relatively small sample from which we derived our GWAS weights owing to the fact that smaller samples are likely to have a higher signal-to-noise ratio compared to larger samples.
