traits. The sample size for FTND was 16,237, excluding the Netherlands Twin Registry sample because some of its subjects were also used in COT GWAS. The sample sizes for TFC and COT were 15,705 and 4,575 respectively. The FTND and TFC measures were derived from the same subjects, therefore, only FTND was used in polygenic analyses. TFC were used only for the identification of shared genes between schizophrenia and ND related phenotypes. The samples used in these 3 ND related GWASs were listed in Supplementary Table S1. All subjects used in this study were of European ancestry.
