newly identified risk alleles with EEG and ERP endophenotypes can help us understand “where in the brain, in which stage, and during what type of information processing the genetic variant has a role”(de Geus, 2010). Importantly, such testing would require substantially smaller samples than a GWAS study (de Geus, 2010). Genetic variants can be screened for functional effects using a broad battery of psychophysiological and behavioral tests, and the resulting “functional profile” can provide important insights into the neurocognitive mechanisms mediating the effects of these genes on behavior.
