Chunk #40 — Discussion — microRNA post-transcriptional regulation of transcript stability via 3’UTR heterogeneity as a mechanism of alcohol tolerance

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Posttranscriptional regulation of BK channel splice variant stability by miR-9 underlies neuroadaptation to alcohol.

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We observed that the ALCOREX exon is always associated with 3’UTR-2.1 but not 3’UTR-2.2. This is in contrast to the STREX exon, which can associate with either UTR. It will be of interest to understand the mechanisms controlling the association of particular exonal concatenations in the coding sequence of mRNA with particular 3’UTRs.