Boardman and colleagues (2008) exploited the design of Add Health to investigate peer and school environment interactions with genetic factors associated with smoking cigarettes among adolescents. In the Add Health in-school survey, respondents nominated up to 10 of their friends who were also in-school survey participants. Adolescents receiving the most friendship nominations can be classified the “most popular” students who shape smoking norms for the larger school community because of their social status and social connections. Boardman and colleagues assessed the smoking behavior of the most popular students and found that school norms favoring smoking (i.e., prevalence of daily smoking among the most popular students) enhanced the associations between genetic factors and daily smoking among all students. Thus, genetic contributions may not emerge unless the environment actively engages individuals in behaviors and reinforces these behaviors. Because the relative contribution of genetics to the daily use of cigarettes is conditional upon school norms related to cigarette use, there are policy opportunities to influence these norms to curb smoking behavior during the critical stage of adolescence, when initiation of smoking can set trajectories for continued use into adulthood.