The Collaborative Study of the Genetics of Alcoholism (COGA) provides another opportunity to examine genes associated with problematic alcohol use. COGA is a multi-site, longitudinal study established to identify vulnerability genes for AD by recruiting multiplex alcohol dependent families as well as representative families from the community14–18. In the current analysis, we performed a family-based GWAS in large multi-generational families severely affected by AD. These families likely represent a subgroup enriched for AD susceptibility alleles.
